Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. - Wikidata - awgldk - TriplyDB

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.

http://www.wikidata.org/entity/Q45215121

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Roles of bioactive sphingolipids in cancer biology and therapeutics The emerging role of FTY720 (Fingolimod) in cancer treatment Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate A review of ceramide analogs as potential anticancer agents High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.The pleiotropic roles of sphingolipid signaling in autophagy The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation Sphingosine kinase 1 in cancer.S1P metabolism in cancer and other pathological conditions.Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation."Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration Cancer treatment strategies targeting sphingolipid metabolism.Roles of sphingosine 1-phosphate on tumorigenesis Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.Targeting sphingosine kinase-1 to inhibit melanoma.Sphingosine kinase 1 as an anticancer therapeutic target.Sphingolipids in cancer: regulation of pathogenesis and therapy.Targeting sphingosine-1-phosphate for cancer therapy A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.Mechanisms linking obesity and cancer Regulation and functions of sphingosine kinases in the brain Targeting SphK1 as a new strategy against cancer.EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells.Cutaneous short-interfering RNA therapy.Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.p53 and Ceramide as Collaborators in the Stress Response Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance Molecular mechanisms of drug resistance and its reversal in cancer.The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells.Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis.Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.

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P2860

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.

http://www.wikidata.org/entity/Q45215121

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P2860

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

Sphingolipid signaling in epidermal homeostasis. Current knowledge and new therapeutic approaches in dermatology.

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1.

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

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