Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.
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Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activationBTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligaseKeap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathwayThe chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genomeThe Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressOverview of Nrf2 as Therapeutic Target in EpilepsyAntioxidant responses and cellular adjustments to oxidative stressRegulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant GenesRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationAntioxidant Functions of the Aryl Hydrocarbon ReceptorTrxR1 as a potent regulator of the Nrf2-Keap1 response systemThe p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcriptionThe Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxiaRedox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degronGenetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.Flavonoids: modulators of brain function?CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathwayOridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive responseNeu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammationAging and immune function: molecular mechanisms to interventionsNrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in MiceAndrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERKBasic principles and emerging concepts in the redox control of transcription factorsLico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 CellsNrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genesAntioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafishFurther structure-activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agentsRegulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascadeZinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogasterKeap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionNrf2:INrf2 (Keap1) signaling in oxidative stressOxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligaseProtection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
P2860
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P2860
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Increased protein stability as ...... f Nrf2 by the 26 S proteasome.
@en
type
label
Increased protein stability as ...... f Nrf2 by the 26 S proteasome.
@en
prefLabel
Increased protein stability as ...... f Nrf2 by the 26 S proteasome.
@en
P2093
P356
P1476
Increased protein stability as ...... f Nrf2 by the 26 S proteasome.
@en
P2093
Cecil B Pickett
Chung S Yang
Philip J Sherratt
Truyen Nguyen
P304
P356
10.1074/JBC.M207293200
P407
P577
2002-11-22T00:00:00Z