Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site
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Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteinsApex1 can cleave complex clustered DNA lesions in cells.Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survivalDelayed repair of radiation induced clustered DNA damage: friend or foe?Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiationDisruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesionsXeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human GenomeInterplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences.Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.Synthesis and thermodynamic studies of oligodeoxyribonucleotides containing tandem lesions of thymidine glycol and 8-oxo-2'-deoxyguanosineThe formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells.Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clustersThe mutagenicity of thymidine glycol in Escherichia coli is increased when it is part of a tandem lesionThe polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY.The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation.In vitro replication and repair studies of tandem lesions containing neighboring thymidine glycol and 8-oxo-7,8-dihydro-2'-deoxyguanosineReduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.Recognition of damaged DNA: structure and dynamic markers.Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage.Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.Induction and repairability of DNA damage caused by ultrasoft X-rays: role of core events.Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli.Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation.Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage.PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?Comparative genomic analysis of the PKS genes in five species and expression analysis in upland cotton.8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.
P2860
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P2860
Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site
description
2004 nî lūn-bûn
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2004年の論文
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name
Enhanced mutagenic potential o ...... in a clustered DNA damage site
@en
type
label
Enhanced mutagenic potential o ...... in a clustered DNA damage site
@en
prefLabel
Enhanced mutagenic potential o ...... in a clustered DNA damage site
@en
P2093
P2860
P356
P1476
Enhanced mutagenic potential o ...... in a clustered DNA damage site
@en
P2093
Colin G Pearson
John Thacker
Naoya Shikazono
Peter O'Neill
P2860
P304
P356
10.1093/NAR/GKH150
P577
2004-01-09T00:00:00Z