cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells.
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The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferationMechanisms of action of glucagon-like peptide 1 in the pancreasChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsExtracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cellsB-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblastsL-histidine sensing by calcium sensing receptor inhibits voltage-dependent calcium channel activity and insulin secretion in β-cells.Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.Small G proteins in islet beta-cell function.Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in miceCOUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathwaysEvidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.Calcineurin signaling regulates human islet {beta}-cell survival.Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback.Proglucagon-derived peptides: mechanisms of action and therapeutic potential.Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activationIncretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose.Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptorsSomatostatin receptor subtype 4 modulates L-type calcium channels via Gβγ and PKC signaling in rat retinal ganglion cellsImpaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment.Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells.Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells.Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promiseGlucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C.Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretinsThe roles of MAPKs in disease.Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signalingGlucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loopRetinal pigment epithelial cells express a functional receptor for glucagon-like peptide-1 (GLP-1).Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling.Role of the glucagon-like-peptide-1 receptor in the control of energy balance.Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects.Glucagon-like peptide-1: modulator of β-cell dysfunction and death.Beta cell connectivity in pancreatic islets: a type 2 diabetes target?Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion.Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1
P2860
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P2860
cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
cAMP-dependent protein kinase ...... de-1 in pancreatic beta-cells.
@en
type
label
cAMP-dependent protein kinase ...... de-1 in pancreatic beta-cells.
@en
prefLabel
cAMP-dependent protein kinase ...... de-1 in pancreatic beta-cells.
@en
P356
P1476
cAMP-dependent protein kinase ...... de-1 in pancreatic beta-cells.
@en
P2093
Edith Gomez
P304
48146-48151
P356
10.1074/JBC.M209165200
P407
P577
2002-10-02T00:00:00Z