Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.
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SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesisGene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control studyBiomarkers of Nutrition for Development-Folate ReviewModeling cellular compartmentation in one-carbon metabolismMethylated nucleosides in tRNA and tRNA methyltransferasesMethotrexate-induced decrease in embryonic 5-methyl-tetrahydrofolate is irreversible with leucovorin supplementationMitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryosMammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissuesA genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysisInfluence of cobalamin scarcity on diatom molecular physiology and identification of a cobalamin acquisition proteinDisruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisAzoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder.Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defectsGNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.Folic acid in early pregnancy: a public health success storyA novel role of the tumor suppressor GNMT in cellular defense against DNA damage.Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiencyDietary folate does not significantly affect the intestinal microbiome, inflammation or tumorigenesis in azoxymethane-dextran sodium sulphate-treated mice.Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health StudyMthfd1 is a modifier of chemically induced intestinal carcinogenesis.Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.Metabolic responses to Orientia tsutsugamushi infection in a mouse modelHuman mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.L-serine in disease and developmentMaternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case reportDNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma.Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNACompetition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus.Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate PathwayFolate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males
P2860
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P2860
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Cytoplasmic serine hydroxymeth ...... enosylmethionine biosyntheses.
@en
type
label
Cytoplasmic serine hydroxymeth ...... enosylmethionine biosyntheses.
@en
prefLabel
Cytoplasmic serine hydroxymeth ...... enosylmethionine biosyntheses.
@en
P2093
P356
P1476
Cytoplasmic serine hydroxymeth ...... enosylmethionine biosyntheses.
@en
P2093
Barry Shane
En-Pei Chiang
Jessica Hills
Katherine Herbig
Ling-Ru Lee
Patrick J Stover
P304
38381-38389
P356
10.1074/JBC.M205000200
P407
P577
2002-08-02T00:00:00Z