Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.
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P1343
Dopamine covalently modifies and functionally inactivates parkinAlpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's modelsCatecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disordersA53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old miceElevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsAlpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cellsEfficient and versatile CRISPR engineering of human neurons in culture to model neurological disordersThe adult human brain harbors multipotent perivascular mesenchymal stem cellsAt low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillationEfficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylationInsights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC regionIKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cellsNitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans.Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neuronsIn vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XLFibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine coreA TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell deathParkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease.Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression.Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopyEndocannabinoid signaling in midbrain dopamine neurons: more than physiology?SOX2 and OCT4 mRNA-expressing cells, detected by molecular beacons, localize to the center of neurospheres during differentiationSystems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.Lineage-specific regulation of epigenetic modifier genes in human liver and brainFibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1.A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine ReuptakeInteraction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Neurodegeneration and neuroprotection in Parkinson disease.Thiol-redox signaling, dopaminergic cell death, and Parkinson's diseaseThe phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein.Reduced expression of α-synuclein in alcoholic brain: influence of SNCA-Rep1 genotype.Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.Drug discovery in Parkinson's disease-Update and developments in the use of cellular models.Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.
P2860
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P2860
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Effect of mutant alpha-synucle ...... human mesencephalic cell line.
@en
type
label
Effect of mutant alpha-synucle ...... human mesencephalic cell line.
@en
prefLabel
Effect of mutant alpha-synucle ...... human mesencephalic cell line.
@en
P2093
P356
P1476
Effect of mutant alpha-synucle ...... human mesencephalic cell line.
@en
P2093
Cecilia Lundberg
Heather K Raymon
Julie Lotharius
Pia Wiekop
P304
38884-38894
P356
10.1074/JBC.M205518200
P407
P4510
P577
2002-07-26T00:00:00Z