What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
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Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.Is the defect in pro-hormone processing in Type 2 diabetes mellitus restricted to the beta cell?Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly.Proinsulin and age in general populationAP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteinsSignificant association of insulin and proinsulin with clustering of cardiovascular risk factors.Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish menIncreased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7.Translational control of glucose-induced islet amyloid polypeptide production in pancreatic isletsGrowth factor control of pancreatic islet regeneration and functionHyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humansChronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.Biophysical alteration of the secretory track in β-cells due to molecular overcrowding: the relevance for diabetes.The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial.Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.β-Cell dysfunction under hyperglycemic stress: a molecular model.A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formationDifferences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2.Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study.Unraveling the aggregation propensity of human insulin C-peptide.Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia.Difference in the influence of maternal and paternal NIDDM on pancreatic beta-cell activity and blood lipids in normoglycaemic non-diabetic adult offspring.Disproportionately elevated proinsulinemia is observed at modestly elevated glucose levels within the normoglycemic range.Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells.
P2860
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P2860
What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
What beta-cell defect could le ...... oinsulin-processing mechanism.
@en
type
label
What beta-cell defect could le ...... oinsulin-processing mechanism.
@en
prefLabel
What beta-cell defect could le ...... oinsulin-processing mechanism.
@en
P356
P1433
P1476
What beta-cell defect could le ...... oinsulin-processing mechanism.
@en
P2093
P304
P356
10.2337/DIAB.43.4.511
P407
P577
1994-04-01T00:00:00Z