A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation
about
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesisMolecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes MellitusOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesIdentification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation.Solution state structures of human pancreatic amylin and pramlintide.Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.Biphasic effects of insulin on islet amyloid polypeptide membrane disruption.The molecular basis of distinct aggregation pathways of islet amyloid polypeptide.Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity.Misfolded proteins in Alzheimer's disease and type II diabetes.Type 2 diabetes as a protein misfolding disease.S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin.Feline models of type 2 diabetes mellitus.β-Cell failure in type 2 diabetes: a case of asking too much of too few?Membrane damage by human islet amyloid polypeptide through fibril growth at the membraneCyclic N-terminal loop of amylin forms non amyloid fibers.The role of the 14-20 domain of the islet amyloid polypeptide in amyloid formationDirect measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry.Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation.Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes.Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state.Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.Acidic pH retards the fibrillization of human Islet Amyloid Polypeptide due to electrostatic repulsion of histidines.Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling.Mass spectrometry and the amyloid problem--how far can we go in the gas phase?
P2860
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P2860
A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
A novel assay in vitro of huma ...... peptides on amyloid formation
@en
A novel assay in vitro of huma ...... peptides on amyloid formation
@nl
type
label
A novel assay in vitro of huma ...... peptides on amyloid formation
@en
A novel assay in vitro of huma ...... peptides on amyloid formation
@nl
prefLabel
A novel assay in vitro of huma ...... peptides on amyloid formation
@en
A novel assay in vitro of huma ...... peptides on amyloid formation
@nl
P2093
P2860
P356
P1433
P1476
A novel assay in vitro of huma ...... peptides on amyloid formation
@en
P2093
N L Eberhardt
P C Butler
P2860
P304
P356
10.1042/BJ3310809
P407
P478
331 ( Pt 3)
P577
1998-05-01T00:00:00Z