Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.
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A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cellsp53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stressInhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetesIslet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK ratHuman mesenchymal stem cells protect human islets from pro-inflammatory cytokines.Anti-apoptotic Effects of Bone Marrow on Human Islets: A Preliminary Report.MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESCCharacterization of membrane-shed microvesicles from cytokine-stimulated β-cells using proteomics strategies.Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes.Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK ratRegulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.Predictors of progression to Type 1 diabetes: preparing for immune interventions in the preclinical disease phase.Islet inflammation in type 2 diabetes.Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.Modulation of secretory granule-targeting efficiency by cis and trans compounding of sorting signals.Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants.Effects of IL-1β-Blocking Therapies in Type 2 Diabetes Mellitus: A Quantitative Systems Pharmacology Modeling Approach to Explore Underlying Mechanisms.IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction.Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis-related genes.Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation.Pro-inflammatory cytokines attenuate glucose-stimulated insulin secretion from INS-1E insulinoma cells by restricting mitochondrial pyruvate oxidation capacity - Novel mechanistic insight from real-time analysis of oxidative phosphorylation.
P2860
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P2860
Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Exposure of human islets to cy ...... y elevated proinsulin release.
@en
type
label
Exposure of human islets to cy ...... y elevated proinsulin release.
@en
prefLabel
Exposure of human islets to cy ...... y elevated proinsulin release.
@en
P2093
P2860
P356
P1476
Exposure of human islets to cy ...... y elevated proinsulin release.
@en
P2093
Eizirik DL
Pavlovic D
Pipeleers DG
Van Schravendijk C
P2860
P356
10.1172/JCI6438
P407
P577
1999-07-01T00:00:00Z