A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.
about
Melanoma: from melanocyte to genetic alterations and clinical optionsMultiple interacting domains contribute to p14ARF mediated inhibition of MDM2Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibitionChimeric negative regulation of p14ARF and TBX1 by a t(9;22) translocation associated with melanoma, deafness, and DNA repair deficiencyGenome-wide association studies of pigmentation and skin cancer: a review and meta-analysisMelanoma genetics and the development of rational therapeutics.Dynamics of ARF regulation that control senescence and cancer.Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblastsComponents of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.Somatic p16(INK4a) loss accelerates melanomagenesisGenetics of familial melanoma: 20 years after CDKN2A.Nucleolar adaptation in human cancerIncreased prevalence of lung, breast, and pancreatic cancers in addition to melanoma risk in families bearing the cyclin-dependent kinase inhibitor 2A mutation: implications for genetic counseling.A flexible multiplex bead-based assay for detecting germline CDKN2A and CDK4 variants in melanoma-prone kindredsMolecular regulation of melanocyte senescence.Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-MycHuman melanocyte senescence and melanoma susceptibility genes.The INK4a/ARF locus and melanoma.Frequent p16-independent inactivation of p14ARF in human melanoma.Pharmacogenetic candidate genes for melanoma.Pocket protein function in melanocyte homeostasis and neoplasia.Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours.Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma.A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL).Therapeutic targets in the ARF tumor suppressor pathway.BRAF(E600) in benign and malignant human tumours.Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanomaFeatures associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.Cutaneous melanoma: how does ultraviolet light contribute to melanocyte transformation?CDKN2A unclassified variants in familial malignant melanoma: combining functional and computational approaches for their assessment.Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma.Novel and recurrent p14 mutations in Italian familial melanoma.New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section.Novel germline CDKN2A mutation associated with head and neck squamous cell carcinomas and melanomas.Pathways from senescence to melanoma: focus on MITF sumoylation.A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility.Regulatory Network of ARF in Cancer Development.A mutation hotspot at the p14ARF splice site.Multiple neurofibromas as the presenting feature of familial atypical multiple malignant melanoma (FAMMM) syndrome.Prevalence of Germline BAP1, CDKN2A, and CDK4 Mutations in an Australian Population-Based Sample of Cutaneous Melanoma Cases.
P2860
Q21284811-84E2E74C-0BF7-4C15-BC10-E5A1E8BAE177Q28207477-09D559CE-8FAB-4671-A0DB-57BBE77E991BQ28215807-5815C354-E536-485D-97F0-E0EC80364765Q28290365-DA5D9058-4DBB-4F7B-A05C-3E5A31A58905Q28744574-7226C8E0-9BAB-46A5-B067-E712FD0068A9Q33726956-6D60617B-C27F-47D8-933D-3E087466016CQ34047232-F5C315EE-16F7-44AB-89C7-BCF6CBD498C4Q34286570-D788BB6A-3ED4-4E08-858C-23D78B035452Q34329975-BCA11C20-15C6-479E-9662-EA5FD2D170ECQ34429099-D968A635-F3AB-4B4D-B98B-3114EF70434CQ34449957-565F59CB-FFF2-4FE5-9216-968CFAD70561Q34452742-A8D76FDC-536E-4C55-9105-24AB1C936848Q34602917-C7676F12-B17B-4970-827A-700A966319ABQ34609753-2C303BAB-27C9-41BA-B153-4A65CC181924Q34722891-7E7B61BC-11F7-46B9-95B8-CA22448DEB67Q35082715-9215C288-21E5-4B9F-8742-76749F370480Q35146545-CDD481B2-DD6D-4720-AF19-02293C4B89F6Q35146563-ED517057-F3BF-47B1-9164-76A60812BB41Q35541602-02BE1181-7299-49AF-9EB8-31BDEEAEF831Q35574952-B73CC10A-61D8-41BC-8B61-B333D265DC50Q36530303-7650B597-902E-463B-A17A-9A0369EBADF8Q36615991-4A000ECD-5653-4736-A847-775D53C214F4Q36694476-F3866B14-0796-46DA-907F-249CA700188CQ36808635-FC282512-62B4-464D-8EAA-4C7EB9A4D9F2Q36879301-884109F7-C57B-4894-B5F6-F0EC94C6DCBAQ36921234-E1C35A87-9EBE-47A0-A4E0-9E29C573B8E2Q36930013-5A370EF0-2797-4833-99AA-10DB8FF81C90Q37004819-A7637FE0-D657-4623-A0A2-90CADD35A7F6Q37352015-2E0B3500-2E4A-47D6-BA25-EE4582999A99Q39012719-EC443F9D-1CF5-4A43-B74C-AAE890841549Q39749283-E5968207-0D04-4698-BCC0-AAD8E86BEA6DQ42647994-CF305CC1-DB31-4CD4-B5E9-3F73D250751AQ42855694-15D1D236-CBAB-4231-BCEA-E0FB8E599242Q44826012-0BD6DDE4-61ED-420E-B1CB-24B889044F06Q47927484-FBD50015-2458-4B5D-ABF6-1F2ABC0173FDQ51686167-83F35FE9-F1ED-400A-8750-E302DB230C67Q52582577-ECF75299-14A6-4429-881A-2EA71F61BC2CQ52857972-E5A4CBEE-21C0-48B8-A2FB-23DBC07B4763Q54435178-BE11647D-0DEB-4C88-88BB-AC217DE5DBB2Q55063850-AFE5B843-F7D1-40FD-AF07-7673BA136F02
P2860
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.
@en
type
label
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.
@en
prefLabel
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.
@en
P2860
P50
P356
P1433
P1476
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF
@en
P2093
Darmanian AP
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204728
P407
P577
2001-09-01T00:00:00Z
P5875
P6179
1033503943