A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency.
about
Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1 gene with missense sequence changes and in-frame deletions, but not polymorphismsThe dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutationsA guide for functional analysis of BRCA1 variants of uncertain significanceExpression patterns of protein kinases correlate with gene architecture and evolutionary rates.Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancerNovel Mutation in Bernard-Soulier Syndrome.Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.Emerging roles of BRCA1 alternative splicing.Role of 5'- and 3'-untranslated regions of mRNAs in human diseases.Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations.Multiple novel alternative splicing forms of FBXW7α have a translational modulatory function and show specific alteration in human cancer.Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors.Clinical Implications of Rabphillin-3A-Like Gene Alterations in Breast Cancer.The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity.Molecular characterization of WFS1 in patients with Wolfram syndromeA synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and functionExtensive allele-specific translational regulation in hybrid mice.Relationship between three novel SNPs of BRCA1 and canine mammary tumors.Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.CCR5Delta32 59537-G/A promoter polymorphism is associated with low translational efficiency and the loss of CCR5Delta32 protective effectsPolysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis.Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression.Functional Impact of Sequence Alterations Found in BRCA1 Promoter/5'UTR Region in Breast/Ovarian Cancer Families from Upper Silesia, Poland.Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients.Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells.Influence of estrogen and variations at the BRCA1 promoter region on transcription and translation.In vivo analysis of translation initiation sites in Plasmodium falciparum.Identification of Single Nucleotide Non-coding Driver Mutations in Cancer.Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE.Identification of novel SNPs in SYK gene of breast cancer patients: computational analysis of SNPs in the 5'UTR.Mutation analysis and mRNA expression of trail-receptors in human breast cancer.Altered expression of melanocortin-1 receptor (MC1R) in a yellow-coloured wild raccoon dog (Nyctereutes procyonoides).Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk.Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors.Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
P2860
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P2860
A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
A somatic mutation in the 5'UT ...... ion of translation efficiency.
@en
type
label
A somatic mutation in the 5'UT ...... ion of translation efficiency.
@en
prefLabel
A somatic mutation in the 5'UT ...... ion of translation efficiency.
@en
P2093
P2860
P50
P356
P1433
P1476
A somatic mutation in the 5'UT ...... tion of translation efficiency
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204620
P407
P577
2001-07-01T00:00:00Z
P5875
P6179
1026215706