Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases.
about
Following a TRAIL: update on a ligand and its five receptorsTAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitmentThe linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.Targeting a novel N-terminal epitope of death receptor 5 triggers tumor cell death.DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosisOxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms.Death receptors in chemotherapy and cancer.Mechanisms of resistance to TRAIL-induced apoptosis in cancer.HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer CellsTRAIL, caspases and maturation of normal and leukemic myeloid precursors.Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2.TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.Towards novel paradigms for cancer therapy.Combined modality therapy with TRAIL or agonistic death receptor antibodies.Focus on skin cancer association and progression under TNF antagonist therapy.Resistance to TRAIL and how to surmount it.TRAIL-beta and TRAIL-gamma: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential.Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines.Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2.Modulation of apoptosis-related cell signalling pathways by curcumin as a strategy to inhibit tumor progression.The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation.Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complexItch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL.Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturationTRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism.Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4.Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexescFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes.Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing.RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages.Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells.
P2860
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P2860
Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Modulation of tumor necrosis f ...... inhibition of apical caspases.
@en
type
label
Modulation of tumor necrosis f ...... inhibition of apical caspases.
@en
prefLabel
Modulation of tumor necrosis f ...... inhibition of apical caspases.
@en
P2093
P2860
P356
P1476
Modulation of tumor necrosis f ...... inhibition of apical caspases.
@en
P2093
P2860
P304
34743-34752
P356
10.1074/JBC.M105693200
P407
P577
2001-07-18T00:00:00Z