Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein BaxOligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channelApoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cellsProapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activityThe role of VDAC in cell death: friend or foe?Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney InjuryCritical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitorOligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondriaFlow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cellsUpregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondriaMono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functionsBid activation in kidney cells following ATP depletion in vitro and ischemia in vivoAge-related changes in the ratio of Mcl-1/Bax expression in the rat cochlea.Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survivalSuppression of colorectal cancer liver metastasis by apolipoprotein(a) kringle V in a nude mouse model through the induction of apoptosis in tumor-associated endothelial cells.Editor's Highlight: Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis.Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration.Targeting mitochondria for resuscitation from cardiac arrest.CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2Expression of Bcl-2 and Bax in mouse renal tubules during kidney development.Small-molecule Bax agonists for cancer therapy.Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated BaxCytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria.Near-infrared photobiomodulation in an animal model of traumatic brain injury: improvements at the behavioral and biochemical levelsInvolvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice.Diva reduces cell death in response to oxidative stress and cytotoxicity.Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma.Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosisA novel role of IGFBP7 in mouse uterus: regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization.Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?Regulated cell death in AKI.Adenovirus E2F1 overexpression sensitizes LNCaP and PC3 prostate tumor cells to radiation in vivo.Deficiency of the Bax gene attenuates denervation-induced apoptosisVinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family membersCharacterization of Cholix toxin-induced apoptosis in HeLa cells.
P2860
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P2860
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
@en
type
label
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
@en
prefLabel
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
@en
P2093
P2860
P356
P1476
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.
@en
P2093
Mikhailov V
Mikhailova M
Pulkrabek DJ
Saikumar P
Venkatachalam MA
P2860
P304
18361-18374
P356
10.1074/JBC.M100655200
P407
P577
2001-02-20T00:00:00Z