The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.
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Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 siteIsolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 geneStructure and expression of the human immunoglobulin lambda genesA novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins.Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancerThe second century of the antibody. Molecular perspectives in regulation, pathophysiology, and therapeutic applications.An immunoglobulin mutator that targets G.C base pairs.Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobasesBSAP can repress enhancer activity by targeting PU.1 function.Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrateGene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappaDeletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in transElucidation of IgH intronic enhancer functions via germ-line deletionAID and somatic hypermutation.EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling.A major deletion in the Vκ-Jκ intervening region results in hyperelevated transcription of proximal Vκ genes and a severely restricted repertoire.Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoireThe Igκ gene enhancers, E3' and Ed, are essential for triggering transcriptionMolecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).Identification of USF as the ubiquitous murine factor that binds to and stimulates transcription from the immunoglobulin lambda 2-chain promoterA new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expressionRegulation of kappa immunoglobulin gene transcription in vitro.Identification of tissue specific nuclear proteins: DNA sequence and protein binding regions in the T cell receptor beta J-C intronThe plasmacytoma J558L lacks constitutively active NF-kappa B and is deficient in early response gene activationPU.1 can participate in an active enhancer complex without its transcriptional activation domain.Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes.Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.Receptor editing: an approach by autoreactive B cells to escape tolerance.Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangementA developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.Vκ gene repertoire and locus contraction are specified by critical DNase I hypersensitive sites within the Vκ-Jκ intervening region.The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.Characterization of the human immunoglobulin kappa gene 3' enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprintsInvolvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation.
P2860
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P2860
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The immunoglobulin kappa locus ...... stream of the constant region.
@en
type
label
The immunoglobulin kappa locus ...... stream of the constant region.
@en
prefLabel
The immunoglobulin kappa locus ...... stream of the constant region.
@en
P2860
P1433
P1476
The immunoglobulin kappa locus ...... stream of the constant region.
@en
P2093
Neuberger MS
P2860
P304
P407
P577
1989-07-01T00:00:00Z