Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes
about
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of BaxYap1 acts downstream of α-catenin to control epidermal proliferationPromotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5The multi-differentiation potential of peripheral blood mononuclear cellsEfp targets 14-3-3 sigma for proteolysis and promotes breast tumour growthImmunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineageThe role of epigenetic inactivation of 14-3-3sigma in human cancerIdentification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouseAnalysis of 14-3-3sigma expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma.Natural and pharmacological regulation of telomeraseAberrant overexpression of an epithelial marker, 14-3-3sigma, in a subset of hematological malignanciesIsoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regenerationP53 suppresses expression of the 14-3-3 gamma oncogene.DNA replication blockade impairs p53-transactivationROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cellsEstimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the assessment of marker gene expression in the lymph nodesA two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere statusImmortalized keratinocyte lines derived from human embryonic stem cellsATM function and telomere stability.P63 expression levels in side population and low light scattering ocular surface epithelial cells.Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes: mechanisms and implications for skin administration.p63 identifies keratinocyte stem cells.The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutationsInduction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytesDownregulation of 14-3-3σ correlates with multistage carcinogenesis and poor prognosis of esophageal squamous cell carcinoma14-3-3σ and p63 play opposing roles in epidermal tumorigenesis.Telomerase as a novel and potentially selective target for cancer chemotherapy.Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.IκB kinase alpha and cancerTransdifferentiation of peripheral blood mononuclear cells into epithelial-like cellsGene therapy in combination with tissue engineering to treat epidermolysis bullosa.Pathophysiology of ocular surface squamous neoplasia14-3-3 sigma positively regulates p53 and suppresses tumor growth.Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis.Actin filament dynamics impacts keratinocyte stem cell maintenance.Regeneration of squamous epithelia from stem cells of cultured grafts.IRF6 in development and disease: a mediator of quiescence and differentiation.
P2860
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P2860
Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Downregulation of 14-3-3sigma ...... of primary human keratinocytes
@en
type
label
Downregulation of 14-3-3sigma ...... of primary human keratinocytes
@en
prefLabel
Downregulation of 14-3-3sigma ...... of primary human keratinocytes
@en
P2093
P2860
P50
P356
P1476
Downregulation of 14-3-3sigma ...... of primary human keratinocytes
@en
P2093
M Molinari
O Golisano
S Bondanza
P2860
P304
P356
10.1083/JCB.149.5.1117
P407
P577
2000-05-01T00:00:00Z