Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis.
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The transcription factor p53: not a repressor, solely an activatorStress-dependent nucleolin mobilization mediated by p53-nucleolin complex formationTDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo.The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteinsScotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membraneStaf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.p21Waf1 expression is regulated by nuclear intermediate filament vimentin in neuroblastoma.Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis.Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation.Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.CD95 is part of a let-7/p53/miR-34 regulatory networkFas receptor-mediated apoptosis: a clinical application?Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescenceDrosophila p53 preserves genomic stability by regulating cell death.Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancerExpression of C-terminal deleted p53 isoforms in neuroblastoma.Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complexp53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated--mice identification of Haeme-oxygenase 1 as a direct p53 target geneRelationship of Fas, FasL, p53 and bcl-2 expression in human non-small cell lung carcinomas.Tissue microarray analysis of Fas and FasL expressions in human non-small cell lung carcinomas; with reference to the p53 and bcl-2 overexpressions.Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain.Census and evaluation of p53 target genes.Replication of damaged DNA in vitro is blocked by p53.Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expressionInterferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively.P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions.Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice.Accumulation of an inactive form of p53 protein in cells treated with TNF alpha.Effect of C-terminal deletion of P53 on heat induced CD95 expression and apoptosis in a rat histiocytoma.IFN-gammaupregulates apoptosis-related molecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma.Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation.Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma.The Roles of P53 and its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis Stage Mouse Embryos.p53: 25 years of research and more questions to answer.A comprehensive study of p53 transcriptional activity in thymus and spleen of gamma irradiated mouse: high sensitivity of genes involved in the two main apoptotic pathways.Alterations of Fas (APO-1/CD 95) gene and its relationship with p53 in non small cell lung cancer
P2860
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P2860
Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Human and mouse Fas (APO-1/CD9 ...... ts unable to induce apoptosis.
@en
type
label
Human and mouse Fas (APO-1/CD9 ...... ts unable to induce apoptosis.
@en
prefLabel
Human and mouse Fas (APO-1/CD9 ...... ts unable to induce apoptosis.
@en
P2093
P2860
P356
P1476
Human and mouse Fas (APO-1/CD9 ...... ts unable to induce apoptosis.
@en
P2093
Bourdon JC
Reisdorf P
Watanabe-Fukunaga R
Yonish-Rouach E
P2860
P304
P356
10.1074/JBC.275.6.3867
P407
P577
2000-02-01T00:00:00Z