SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. - Wikidata - awgldk - TriplyDB

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

http://www.wikidata.org/entity/Q40919280

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The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2 TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1 Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy Functional roles of Syk in macrophage-mediated inflammatory responses Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells.Analysis of FcgammaRIIA cytoplasmic tail requirements in signaling for serotonin secretion: evidence for an ITAM-dependent, PI3K-dependent pathway Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.Back to the future: oral targeted therapy for RA and other autoimmune diseases.Beyond the RING: CBL proteins as multivalent adapters.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Genetic analysis of integrin activation in T lymphocytes.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.p110δ PI3 kinase pathway: emerging roles in cancer.Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL Syk and pTyr'd: Signaling through the B cell antigen receptor Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas.The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment.Regulation of immune responses by proton channels.Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 production through the activation of Bruton's tyrosine kinase and STAT3.Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies.CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis.TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.A unique function for cyclin D3 in early B cell development.

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P2860

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

http://www.wikidata.org/entity/Q40919280

description

1999 nî lūn-bûn

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

@zh-my

1999年学术文章

@zh-sg

1999年學術文章

@yue

1999年學術文章

@zh

1999年學術文章

@zh-hant

name

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

@en

type

label

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

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prefLabel

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

@en

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Journal of Biological Chemistry

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SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

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P2093

A M Scharenberg

http://www.w3.org/2001/XMLSchema#string

D A Fruman

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L C Cantley

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L O Beitz

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T Kurosaki

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P2860

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate

Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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32662-32666

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46

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