Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
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Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected FindingChronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsIon channels as drug targets in central nervous system disordersCalpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse modelInhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleusHAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neuronsDisturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.Tetrabenazine is neuroprotective in Huntington's disease mice.Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic miceLack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.The selective vulnerability of nerve cells in Huntington's disease.Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin.Role of inositol 1,4,5-trisphosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxiasNeuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.Dopaminergic signaling and striatal neurodegeneration in Huntington's disease.The paradigm of Huntington's disease: therapeutic opportunities in neurodegeneration.Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.Differences in excitatory transmission between thalamic and cortical afferents to single spiny efferent neurons of rat dorsal striatumInositol 1,4,5-tripshosphate receptor, calcium signaling, and polyglutamine expansion disorders.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationGinsenosides protect striatal neurons in a cellular model of Huntington's disease.Endogenous neuroprotection in chronic neurodegenerative disorders: with particular regard to the kynurenines.Dopamine and glutamate in Huntington's disease: A balancing act.Huntington's disease and Group I metabotropic glutamate receptors.Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Ca(2+) signaling: an outlook on the characterization of Ca(2+) channels and their importance in cellular functionsProtein oxidation in Huntington disease.NMDARs in neurological diseases: a potential therapeutic target.Metabotropic glutamate receptor 5 as a potential therapeutic target in Huntington's disease.Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium.Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Control of excitatory synaptic transmission by C-terminal Src kinase.Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.Inhibition of N-methyl-D-aspartate-activated current by bis(7)-tacrine in HEK-293 cells expressing NR1/NR2A or NR1/NR2B receptors.NMDAR hypofunction and somatostatin-expressing GABAergic interneurons and receptors: A newly identified correlation and its effects in schizophrenia.Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus.
P2860
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P2860
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
@en
type
label
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
@en
prefLabel
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
@en
P2093
P2860
P1476
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
@en
P2093
P2860
P304
P356
10.1046/J.1471-4159.1999.0721890.X
P407
P577
1999-05-01T00:00:00Z