The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
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Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiamSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factorHelix-loop-helix proteins: regulators of transcription in eucaryotic organismsRegulation of pT alpha gene expression by a dosage of E2A, HEB, and SCLGradient of E2A activity in B-cell development.Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient miceThe DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in miceThe TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursorsDecoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1Role for homodimerization in growth deregulation by E2a fusion proteins.Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient miceEnhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceChronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsEctopic expression of E47 or E12 promotes the death of E2A-deficient lymphomasThe t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 geneTranscriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance.Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells.E proteins regulate osteoclast maturation and survival.Notch-regulated periphery B cell differentiation involves suppression of E protein function.Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets.Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activitiesNotch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.Systematic identification of transcription factors associated with patient survival in cancers.Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
P2860
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P2860
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
@en
type
label
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
@en
prefLabel
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
@en
P2860
P356
P1476
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
@en
P2860
P304
P356
10.1074/JBC.273.12.7030
P407
P577
1998-03-01T00:00:00Z