DNA topoisomerase II mutations and resistance to anti-tumor drugs.
about
Characterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase IIInfluence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity.Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalphaEctopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide.The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.DNA topoisomerase II, genotoxicity, and cancerSubstituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres.Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiaeImpaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani.Apurinic sites are position-specific topoisomerase II poisons.
P2860
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P2860
DNA topoisomerase II mutations and resistance to anti-tumor drugs.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
DNA topoisomerase II mutations and resistance to anti-tumor drugs.
@en
type
label
DNA topoisomerase II mutations and resistance to anti-tumor drugs.
@en
prefLabel
DNA topoisomerase II mutations and resistance to anti-tumor drugs.
@en
P2860
P356
P1433
P1476
DNA topoisomerase II mutations and resistance to anti-tumor drugs.
@en
P2093
P2860
P304
P356
10.1002/BIES.950170906
P407
P577
1995-09-01T00:00:00Z