Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.
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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)Fission and selective fusion govern mitochondrial segregation and elimination by autophagyStable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide productionDeletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cellsAcyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independentlyThe Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcriptInsulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice.Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerolPhysiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines.Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic traitRIP140 represses the "brown-in-white" adipocyte program including a futile cycle of triacylglycerol breakdown and synthesis.Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.Cell type-specific activation of metabolism reveals that beta-cell secretion suppresses glucagon release from alpha-cells in rat pancreatic islets.A futile metabolic cycle activated in adipocytes by antidiabetic agents.Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.Inhibiting long-chain fatty acyl CoA synthetase does not increase agonist-induced release of arachidonate metabolites from human endothelial cells.Effects of modulation of glycerol kinase expression on lipid and carbohydrate metabolism in human muscle cells.IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.Implications of Aquaglyceroporin 7 in Energy Metabolism.Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase.Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.
P2860
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P2860
Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Engineering of glycerol-stimul ...... f stimulus-secretion coupling.
@en
type
label
Engineering of glycerol-stimul ...... f stimulus-secretion coupling.
@en
prefLabel
Engineering of glycerol-stimul ...... f stimulus-secretion coupling.
@en
P2093
P2860
P356
P1476
Engineering of glycerol-stimul ...... f stimulus-secretion coupling.
@en
P2093
C B Newgard
J D McGarry
P A Antinozzi
P2860
P304
18621-18627
P356
10.1074/JBC.272.30.18621
P407
P577
1997-07-01T00:00:00Z