Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.
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A novel glucokinase regulator in pancreatic beta cells: precursor of propionyl-CoA carboxylase beta subunit interacts with glucokinase and augments its activityCNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretionOverexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretionAdenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretionContributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa ratsCo-localization of glucokinase with actin filamentsCharacterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young ageTrefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.Cellular origin of hexokinase in pancreatic islets.Interactions between insulin resistance and insulin secretion in the development of glucose intolerance.Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.Functional diversification and specialization of cytosolic 70-kDa heat shock proteins.Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activationModulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase.Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experimentRestoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.Detailed molecular analysis of the induction of the L-PK gene by glucose.Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta-cells.Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines.Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate.Overexpression of either liver type or pancreatic beta cell type glucokinase via recombinant adenovirus enhances glucose oxidation in isolated rat hepatocytes.Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase.Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate.Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia.Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes.Regulation of secretory granule pH in insulin-secreting cells.Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression.The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism.Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.Functional glucokinase isoforms are expressed in rat brain.Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes.
P2860
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P2860
Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Differential effects of overex ...... f the high and low Km enzymes.
@en
type
label
Differential effects of overex ...... f the high and low Km enzymes.
@en
prefLabel
Differential effects of overex ...... f the high and low Km enzymes.
@en
P2093
P2860
P356
P1476
Differential effects of overex ...... f the high and low Km enzymes.
@en
P2093
Johnson JH
Newgard CB
Tokuyama Y
P2860
P304
P356
10.1074/JBC.271.1.390
P407
P577
1996-01-01T00:00:00Z