Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
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The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliencyPotential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonistSelective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonismType I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious ratsNeuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative diseaseThe glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's diseaseCarrier-mediated delivery of metabotrophic glutamate receptor ligands to the central nervous system: structural tolerance and potential of the L-system amino acid transporter at the blood-brain barrierSTDP in a bistable synapse model based on CaMKII and associated signaling pathwaysN-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus InfectionPerspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?Allosteric modulation of metabotropic glutamate receptors.Advances in the treatment of anxiety: targeting glutamate.Assessment of neuroprotection in the retina with DARC.Current concepts in the pathophysiology of glaucomaActivation of mGlu3 receptors stimulates the production of GDNF in striatal neurons.Metabotropic glutamate receptors: novel targets for pain relief.Metabotropic glutamate receptors as a new therapeutic target for malignant gliomasAlterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.Effects of transmitters and amyloid-beta peptide on calcium signals in rat cortical astrocytes: Fura-2AM measurements and stochastic model simulationsRegulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.Time-dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina.Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stressAnticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.Therapeutic potential of mGluR5 targeting in Alzheimer's diseasePotentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase.Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology.TREK-1, a K+ channel involved in neuroprotection and general anesthesia.Heat shock enhances CMV-IE promoter-driven metabotropic glutamate receptor expression and toxicity in transfected cells.Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptorsMechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channelsNeural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targetsAgonists and antagonists of metabotropic glutamate receptors: anticonvulsants and antiepileptogenic agents?Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases.Multifunctional drugs with different CNS targets for neuropsychiatric disorders.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbersRole of K(ATP) channels in protection against neuronal excitatory insults.Pharmacological enhancement of neuronal survival.Microfluidics: a new cosset for neurobiology.
P2860
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P2860
Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Metabotropic glutamate recepto ...... f neurodegenerative disorders?
@en
type
label
Metabotropic glutamate recepto ...... f neurodegenerative disorders?
@en
prefLabel
Metabotropic glutamate recepto ...... f neurodegenerative disorders?
@en
P50
P1476
Metabotropic glutamate recepto ...... f neurodegenerative disorders?
@en
P2093
P304
P356
10.1016/S0166-2236(96)20019-0
P577
1996-07-01T00:00:00Z