APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. - Wikidata - awgldk - TriplyDB

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

http://www.wikidata.org/entity/Q41154841

about

The current view for the silencing of the spindle assembly checkpoint Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation Spatiotemporal regulation of the anaphase-promoting complex in mitosis Microtubule-dependent regulation of mitotic protein degradation.Kinetic framework of spindle assembly checkpoint signalling Molecular architecture and mechanism of the anaphase-promoting complex Molecular basis of APC/C regulation by the spindle assembly checkpoint.Enhanced protein degradation by branched ubiquitin chains.PTEN is a negative regulator of mitotic checkpoint complex during the cell cycle Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models The biochemistry of mitosis RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex The Colossus of ubiquitylation: decrypting a cellular code.An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.Mechanism of APC/CCDC20 activation by mitotic phosphorylation.Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly.Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel Molecular mechanisms creating bistable switches at cell cycle transitions.WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.Panta rhei: the APC/C at steady state.Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.Sharpening the anaphase switch.Understanding the structural basis for controlling chromosome division.Measuring APC/C-Dependent Ubiquitylation In Vitro.Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.Regulation of mitotic progression by the spindle assembly checkpoint Decoding sORF translation - from small proteins to gene regulation.Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast Mining for Micropeptides.EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole.Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.

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P2860

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

http://www.wikidata.org/entity/Q41154841

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

APC15 mediates CDC20 autoubiqu ...... he mitotic checkpoint complex.

@en

type

label

APC15 mediates CDC20 autoubiqu ...... he mitotic checkpoint complex.

@en

prefLabel

APC15 mediates CDC20 autoubiqu ...... he mitotic checkpoint complex.

@en

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Nature Structural & Molecular Biology

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APC15 mediates CDC20 autoubiqu ...... the mitotic checkpoint complex

@en

P2093

Billy T Dye

http://www.w3.org/2001/XMLSchema#string

Hannelore Schutz

http://www.w3.org/2001/XMLSchema#string

Holger Stark

http://www.w3.org/2001/XMLSchema#string

Ina Poser

http://www.w3.org/2001/XMLSchema#string

Jan-Michael Peters

http://www.w3.org/2001/XMLSchema#string

Kristina Uzunova

http://www.w3.org/2001/XMLSchema#string

Marc A Jarvis

http://www.w3.org/2001/XMLSchema#string

Maria Novatchkova

http://www.w3.org/2001/XMLSchema#string

Nicholas G Brown

http://www.w3.org/2001/XMLSchema#string

Yusuke Toyoda

http://www.w3.org/2001/XMLSchema#string

P2860

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C

The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint

p31comet blocks Mad2 activation through structural mimicry

Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage

Systematic analysis of human protein complexes identifies chromosome segregation proteins

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

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1116-1123

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scholarly article

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10.1038/NSMB.2412

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11

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19

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Anthony A. Hyman

Brenda A Schulman

P577

2012-09-24T00:00:00Z

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231175916

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23007861

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3498062

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