Structural features of the cytoplasmic region of CD4 required for internalization.
about
Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lckHuman immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailPhosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal regionDifferential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartmentsModification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4Exit of major histocompatibility complex class II-invariant chain p35 complexes from the endoplasmic reticulum is modulated by phosphorylation.Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetatePhorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.Sequences present in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein.Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infectionThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylationDisruption of the CD4-p56lck complex is required for rapid internalization of CD4.Signals for retention of transmembrane proteins in the endoplasmic reticulum studied with CD4 truncation mutants.Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues.Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens.Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.Role of CD4 endocytosis in human immunodeficiency virus infection.Identification of the phosphorylation sequence in the cytoplasmic tail of the varicella-zoster virus Fc receptor glycoprotein gpI.Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies.Modulation of CD4 lateral mobility in intact cells by an intracellularly applied antibodyCD50 (intercellular adhesion molecule 3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line.The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pitsThe TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network.Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting.Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation.
P2860
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P2860
Structural features of the cytoplasmic region of CD4 required for internalization.
description
1990 nî lūn-bûn
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1990年の論文
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1990年論文
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1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
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1990年论文
@wuu
1990年论文
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1990年论文
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name
Structural features of the cytoplasmic region of CD4 required for internalization.
@en
type
label
Structural features of the cytoplasmic region of CD4 required for internalization.
@en
prefLabel
Structural features of the cytoplasmic region of CD4 required for internalization.
@en
P2093
P2860
P1433
P1476
Structural features of the cytoplasmic region of CD4 required for internalization.
@en
P2093
P2860
P304
P407
P577
1990-02-01T00:00:00Z