Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation.
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Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease modelsTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.Cellular localization of Nicastrin affects amyloid beta species productionA role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease.Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.Molecular pharmacology of the secretin receptorCloning of a bovine orphan transporter and its short splicing variant.Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.Label-free microcavity biosensors: steps towards personalized medicine.The amyloid beta ion channel hypothesis of Alzheimer's disease.Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 miceBrain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein.Monoclonal antibodies to a 100-kd protein reveal abundant A beta-negative plaques throughout gray matter of Alzheimer's disease brains.Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax.Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture.Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors.Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation.Specific mechanism for blood inflow stimulation in brain area prone to Alzheimer's disease lesions.Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis.GM1 ganglioside regulates the proteolysis of amyloid precursor protein.gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation.gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein.Mechanisms of spontaneous cytosolic Ca2+ transients in differentiated human neuronal cells.X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion.Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin.
P2860
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P2860
Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Amyloids beta40 and beta42 are ...... ion increases with maturation.
@en
type
label
Amyloids beta40 and beta42 are ...... ion increases with maturation.
@en
prefLabel
Amyloids beta40 and beta42 are ...... ion increases with maturation.
@en
P2093
P356
P1476
Amyloids beta40 and beta42 are ...... ion increases with maturation.
@en
P2093
P304
P356
10.1074/JBC.271.15.8966
P407
P577
1996-04-01T00:00:00Z