Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites.
about
Randomization of the receptor alpha chain recruitment epitope reveals a functional interleukin-5 with charge depletion in the CD loop.Coiled coil miniprotein randomization on phage leads to charge pattern mimicry of the receptor recognition determinant of interleukin 5.Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for functionInterleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthmaBovine type I interferon receptor protein BoIFNAR-1 has high-affinity and broad specificity for human type I interferons.Interleukin 5 interactions with soluble and cell surface forms of its receptor.Biological and molecular characteristics of interleukin-5 and its receptor.Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits.Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation.Spatial Orientation of the α and βcReceptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs
P2860
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P2860
Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Single chain human interleukin ...... apping receptor binding sites.
@en
type
label
Single chain human interleukin ...... apping receptor binding sites.
@en
prefLabel
Single chain human interleukin ...... apping receptor binding sites.
@en
P2093
P2860
P356
P1476
Single chain human interleukin ...... apping receptor binding sites.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.4.1817
P407
P577
1996-01-01T00:00:00Z