Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist. - Wikidata - awgldk - TriplyDB

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

http://www.wikidata.org/entity/Q34297178

about

Structural basis of interleukin-5 dimer recognition by its α receptor Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13 A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation Interleukin-5 and IL-5 receptor in health and diseases Randomization of the receptor alpha chain recruitment epitope reveals a functional interleukin-5 with charge depletion in the CD loop.A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains Receptor epitope usage by an interleukin-5 mimetic peptide.Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation Cytokines in asthma.IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Interleukin-5, a therapeutic target in allergic inflammation Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.New approaches in the treatment of asthma.The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.Interleukin-5: a novel target for asthma therapy.ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging Cloning and sequencing of an ovine interleukin-5 cDNA.Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly.Biological implications of glycosaminoglycan interactions with haemopoietic cytokines.The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.The GM-CSF receptor family: mechanism of activation and implications for disease.Identification of amino acid residues critical for biological activity in human interleukin-18.Glioblastoma exosomes and IGF-1R/AS-ODN are immunogenic stimuli in a translational research immunotherapy paradigm.Expression and in vitro properties of guinea pig IL-5: comparison to human and murine orthologs.Bacteria displaying interleukin-4 mutants stimulate mammalian cells and reflect the biological activities of variant soluble cytokines.Neutralizing monoclonal antibodies can potentiate IL-5 signaling.Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites.Interleukin 5 interactions with soluble and cell surface forms of its receptor.Biological and molecular characteristics of interleukin-5 and its receptor.Analysis of three human interleukin 5 structures suggests a possible receptor binding mechanism.Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits.An interleukin 5 mutant distinguishes between two functional responses in human eosinophils.Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation.Spatial Orientation of the α and βcReceptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs Defining the Regions of Human Interleukin-5 Important in Receptor Binding and Cellular Activation

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P2860

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

http://www.wikidata.org/entity/Q34297178

description

1995 nî lūn-bûn

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1995 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1995 թվականի մայիսին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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name

Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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type

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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PNAS.92.11.5194

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Proceedings of the National Academy of Sciences of the United States of America

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Identification of receptor-bin ...... 5-derived receptor antagonist.

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Devos R

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Guisez Y

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Oefner C

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Plaetinck G

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Tavernier J

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Tuypens T

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Van der Heyden J

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Verhee A

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P2860

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue

Molecular cloning and expression of the human interleukin 5 receptor

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family

Reconstitution of the functional receptors for murine and human interleukin 5

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF

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5194-5198

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scholarly article

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10.1073/PNAS.92.11.5194

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11

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92

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15436664

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7761472

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