EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism.
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Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilinMetallothionein mediates leukocyte chemotaxis.Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistenceA Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in miceCdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cellsRelationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulationEpidermal growth factor receptor distribution during chemotactic responses.Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension.N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cellsPhosphorylation of the Arp2/3 complex is necessary to nucleate actin filamentsSpatial regulation of RhoC activity defines protrusion formation in migrating cellsN-terminal domains of the class ia phosphoinositide 3-kinase regulatory subunit play a role in cytoskeletal but not mitogenic signaling.Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion.Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions.A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment.Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumorsThe distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migrationReal-time monitoring of cell protrusion dynamics by impedance responses.High-resolution live-cell imaging and time-lapse microscopy of invadopodium dynamics and tracking analysis.Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion.Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway.Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusionsAn in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods.Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration.Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation.Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancerRapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells.N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumorsCofilin determines the migration behavior and turning frequency of metastatic cancer cells.beta-Actin messenger RNA localization and protein synthesis augment cell motility.Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis.The physiological significance of beta -actin mRNA localization in determining cell polarity and directional motility.Local signaling by the EGF receptor.Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension.Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasisZBP1 enhances cell polarity and reduces chemotaxis.
P2860
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P2860
EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
EGF stimulates lamellipod exte ...... an actin-dependent mechanism.
@en
type
label
EGF stimulates lamellipod exte ...... an actin-dependent mechanism.
@en
prefLabel
EGF stimulates lamellipod exte ...... an actin-dependent mechanism.
@en
P2093
P2860
P356
P1476
EGF stimulates lamellipod exte ...... an actin-dependent mechanism.
@en
P2093
J Condeelis
J E Segall
S Masseling
P2860
P2888
P356
10.1007/BF00157687
P577
1996-01-01T00:00:00Z
P6179
1016265760