Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region - Wikidata - awgldk - TriplyDB

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

http://www.wikidata.org/entity/Q41306886

about

Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting Peptide length determines the outcome of TCR/peptide-MHCI engagement Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures Peptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition.Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs Properties and applications of single-chain major histocompatibility complex class I molecules.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus.Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers.High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow.Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.Tricks with tetramers: how to get the most from multimeric peptide-MHC.CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.Immunoinformatics and modeling perspective of T cell epitope-based cancer immunotherapy: a holistic picture.MHC-peptide tetramers for the analysis of antigen-specific T cells.The molecular determinants of CD8 co-receptor function.Functional avidity: a measure to predict the efficacy of effector T cells?Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.Targeting Hsp70: A possible therapy for cancer.Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells.Streptamer technology allows accurate and specific detection of CMV-specific HLA-A*02 CD8+ T cells by flow cytometry.CD8 controls T cell cross-reactivity.Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity.MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition.Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

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Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

http://www.wikidata.org/entity/Q41306886

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Enhanced immunogenicity of CTL ...... g MHC class I invariant region

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Enhanced immunogenicity of CTL ...... g MHC class I invariant region

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Enhanced immunogenicity of CTL ...... g MHC class I invariant region

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P1433

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European Journal of Immunology

P1476

Enhanced immunogenicity of CTL ...... g MHC class I invariant region

@en

P2093

Anna Lissina

http://www.w3.org/2001/XMLSchema#string

Bruno Laugel

http://www.w3.org/2001/XMLSchema#string

Emma Gostick

http://www.w3.org/2001/XMLSchema#string

Fareed Mirza

http://www.w3.org/2001/XMLSchema#string

Hugo A van den Berg

http://www.w3.org/2001/XMLSchema#string

Jonathan M Boulter

http://www.w3.org/2001/XMLSchema#string

Jonathan Vernazza

http://www.w3.org/2001/XMLSchema#string

Linda Wooldridge

http://www.w3.org/2001/XMLSchema#string

Meir Glick

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P Rod Dunbar

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P2860

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

Thymic selection generates a large T cell pool recognizing a self-peptide in humans

Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha

CD3 delta establishes a functional link between the T cell receptor and CD8

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

Phenotypic analysis of antigen-specific T lymphocytes

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

Orientation of the Ig domains of CD8 alpha beta relative to MHC class I.

Interactions between MHC molecules and co-receptors of the TCR.

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1323-1333

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scholarly article

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10.1002/EJI.200636765

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P407

P433

5

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P478

37

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Vincenzo Cerundolo

Andrew K Sewell

P577

2007-05-01T00:00:00Z

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P5875

6398337

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17429845

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P932

2699427

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