A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity.
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HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxisBinding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef proteinStructure--function relationships in HIV-1 Nef.Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsActivation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complexSeparable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signalingThe Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrixNef-mediated clathrin-coated pit formationThe association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependentA hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.The HIV-1 Nef protein as a target for antiretroviral therapy.Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-thetaRegions of human immunodeficiency virus type 1 nef required for function in vivoRole of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaquesThe SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 NefGenetic characterization of HIV type 1 Nef-induced vesicle secretionInhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nefVirion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionReconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex.Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptorsIntra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 NefProspects for an HIV vaccine: conventional approaches and DNA immunization.Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral proteaseInduction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetateThe nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable.Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinaseMechanisms of HIV-1 Nef function and intracellular signaling.HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.The T-cell receptor zeta chain contains two homologous domains with which simian immunodeficiency virus Nef interacts and mediates down-modulation.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.HIV-1 Nef and T-cell activation: a history of contradictions.p21-activated kinase 1 plays a critical role in cellular activation by Nef.
P2860
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P2860
A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
A conserved domain and membran ...... llular serine kinase activity.
@en
type
label
A conserved domain and membran ...... llular serine kinase activity.
@en
prefLabel
A conserved domain and membran ...... llular serine kinase activity.
@en
P2093
P2860
P356
P1476
A conserved domain and membran ...... llular serine kinase activity.
@en
P2093
P2860
P304
15307-15314
P356
10.1074/JBC.270.25.15307
P407
P577
1995-06-01T00:00:00Z