p21-activated kinase 1 plays a critical role in cellular activation by Nef.
about
Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivitySubunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machineryStructure--function relationships in HIV-1 Nef.Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptinsRegulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activationLentivirus Nef specifically activates Pak2.The HIV-1 Nef protein as a target for antiretroviral therapy.Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.HIV's Nef interacts with β-catenin of the Wnt signaling pathway in HEK293 cells"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infectionGenetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolatesNef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivityPulmonary hypertension associated with HIV infection: pulmonary vascular disease: the global perspectiveHuman immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIXLIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytesNetwork-based prediction and analysis of HIV dependency factorsNef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressorsVav proteins, adaptors and cell signaling.PAK1 as a therapeutic target.Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.Interplay between HIV-1 infection and host microRNAs.Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.HIV-1 Nef and T-cell activation: a history of contradictions.HIV-1 Nef: hacker of the host cell.Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrixHuman immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor NefHuman immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid raftsThe HIV-1 Nef protein and phagocyte NADPH oxidase activation.p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection.PAK family kinases: Physiological roles and regulation.Involvement of the Rac1-IRSp53-Wave2-Arp2/3 Signaling Pathway in HIV-1 Gag Particle Release in CD4 T Cells.
P2860
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P2860
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
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p21-activated kinase 1 plays a critical role in cellular activation by Nef.
@en
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
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p21-activated kinase 1 plays a critical role in cellular activation by Nef.
@en
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
@nl
prefLabel
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
@en
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
@nl
P2093
P2860
P1476
p21-activated kinase 1 plays a critical role in cellular activation by Nef
@en
P2093
A S Alberts
B M Peterlin
P2860
P304
P356
10.1128/MCB.20.7.2619-2627.2000
P407
P577
2000-04-01T00:00:00Z