Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.
about
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor proteinStructural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathyAmyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assembliesSelective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interactionAn update on the amyloid hypothesis.Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakness.Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes.Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopModulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.Behavior of neural stem cells in the Alzheimer brain.Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression.Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid.Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive.The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein.A unifying hypothesis of Alzheimer's disease. III. Risk factors.Alzheimer's disease amyloid precursor protein (ApPP): proteolytic processing, secretases and βA4 amyloid production
P2860
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P2860
Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Altered cleavage and secretion ...... Alzheimer's disease mutation.
@en
type
label
Altered cleavage and secretion ...... Alzheimer's disease mutation.
@en
prefLabel
Altered cleavage and secretion ...... Alzheimer's disease mutation.
@en
P2093
P2860
P356
P1433
P1476
Altered cleavage and secretion ...... Alzheimer's disease mutation.
@en
P2093
Felsenstein KM
Hunihan LW
Roberts SB
P2860
P2888
P304
P356
10.1038/NG0394-251
P407
P577
1994-03-01T00:00:00Z
P6179
1037990547