The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7.
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P1343
Misguided transcriptional elongation causes mixed lineage leukemiac-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.Diagnostic tool for the identification of MLL rearrangements including unknown partner genesNovel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11)Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cellThe structure of the human ALL-1/MLL/HRX gene.ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA.Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model.NF-kappaB activation mediates resistance to IFN beta in MLL-rearranged acute lymphoblastic leukemiaDietary resveratrol does not delay engraftment, sensitize to vincristine or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice.Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model.RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.AAV-mediated local delivery of interferon-beta for the treatment of retinoblastoma in preclinical modelsA dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells.MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylationTargeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.Occurrence and modulation of therapeutic targets of Aurora kinase inhibition in pediatric acute leukemia cells.A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting.Cytotoxicity, drug combinability, and biological correlates of ABT-737 against acute lymphoblastic leukemia cells with MLL rearrangement.A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner.Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11).Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression.Establishment and genetic characterization of a novel mixed-phenotype acute leukemia cell line with EP300-ZNF384 fusion.Double-strand DNA break formation mediated by flap endonuclease-1.PreB1 (CD10-) acute lymphoblastic leukemia: immunophenotypic and genomic characteristics, clinical features and outcome in 38 adults and 26 children. The Groupe dEtude Immunologique des Leucémies.A highly specific and sensitive fluorescence in situ hybridization assay for the detection of t(4;11)(q21;q23) and concurrent submicroscopic deletions in acute leukaemias.The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).MLL-mediated transcriptional gene regulation investigated by gene expression profiling.Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements.
P2860
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P2860
The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The acute lymphoblastic leukae ...... d responsive to interleukin-7.
@en
type
label
The acute lymphoblastic leukae ...... d responsive to interleukin-7.
@en
prefLabel
The acute lymphoblastic leukae ...... d responsive to interleukin-7.
@en
P2093
P2860
P1476
The acute lymphoblastic leukae ...... d responsive to interleukin-7.
@en
P2093
Bartram CR
Gramatzki M
Hansen-Hagge TE
Trautmann U
P2860
P304
P356
10.1111/J.1365-2141.1994.TB04726.X
P407
P4510
P577
1994-02-01T00:00:00Z