The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.
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Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-IThe Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyA conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cellsIbrutinib (PCI-32765) in chronic lymphocytic leukemiaB cells in chronic graft-versus-host diseaseRegulatory phosphorylation of Ikaros by Bruton's tyrosine kinaseDetailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma CellsLocalization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms.A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.Ibrutinib: a new frontier in the treatment of chronic lymphocytic leukemia by Bruton's tyrosine kinase inhibitionIrreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model.Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells.Oncogenic activation of NF-kappaB.Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cellsDistinct roles of adenylyl cyclase VII in regulating the immune responses in miceMolecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient miceIbrutinib treatment ameliorates murine chronic graft-versus-host disease.Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphomaInhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in MiceTargeting B cells for the treatment of rheumatoid arthritisA critical appraisal of ibrutinib in the treatment of mantle cell lymphoma and chronic lymphocytic leukemiaBruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral responseCD19 expression in B cells is important for suppression of contact hypersensitivity.Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.Initial treatment of CLL: integrating biology and functional status.Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cellsIbrutinib: a paradigm shift in management of CLL.HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritisBmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing.Primary immunodeficiencies of the B lymphocyteBtk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK.Naturally occurring Bruton's tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model.Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.Btk regulates multiple stages in the development and survival of B-1 cells.How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD
P2860
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P2860
The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@ast
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@en
type
label
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@ast
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@en
prefLabel
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@ast
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@en
P1476
The role of Bruton's tyrosine ...... nction: a genetic perspective.
@en
P2093
Satterthwaite AB
P304
P356
10.1034/J.1600-065X.2000.017504.X
P577
2000-06-01T00:00:00Z