Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296.
about
Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinolSignaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin IIThe structural basis of agonist-induced activation in constitutively active rhodopsinStabilized G protein binding site in the structure of constitutively active metarhodopsin-IIRetinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt diseaseMechanisms of opsin activationSynthesis and characterization of a novel retinylamine analog inhibitor of constitutively active rhodopsin mutants found in patients with autosomal dominant retinitis pigmentosaConstitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix sevenThe structure and function of G-protein-coupled receptorsThe human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domains.Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line.Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor.Microsecond time-resolved circular dichroism of rhodopsin photointermediates.The C9 methyl group of retinal interacts with glycine-121 in rhodopsin.Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells.Covalent bond between ligand and receptor required for efficient activation in rhodopsin.Photoactivation of rhodopsin involves alterations in cysteine side chains: detection of an S-H band in the Meta I-->Meta II FTIR difference spectrumMolecular dynamics investigation of primary photoinduced events in the activation of rhodopsin.Action of molecular switches in GPCRs--theoretical and experimental studies.Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosaLigand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin.Highly conserved tyrosine stabilizes the active state of rhodopsin.Comparison of class A and D G protein-coupled receptors: common features in structure and activation.Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducinLocation of the retinal chromophore in the activated state of rhodopsin*.Conformational selection and equilibrium governs the ability of retinals to bind opsin.Molecular Architecture of G Protein-Coupled Receptors.Stabilization of G protein-coupled receptors by point mutations.Photochemical nature of parietopsin.Single amino acid residue as a functional determinant of rod and cone visual pigments.Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphologyCyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition.Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanismEffect of 11-cis 13-demethylretinal on phototransduction in bleach-adapted rod and cone photoreceptors.Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.A local electrostatic change is the cause of the large-scale protein conformation shift in bacteriorhodopsin.11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle.Assays for inverse agonists in the visual system
P2860
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P2860
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296.
@en
type
label
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296.
@en
prefLabel
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296.
@en
P2093
P356
P1433
P1476
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296.
@en
P2093
D D Oprian
P R Robinson
P304
12592-12601
P356
10.1021/BI00165A008
P407
P577
1992-12-01T00:00:00Z