A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.
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Regulation of human p53 activity and cell localization by alternative splicingInteraction of p53 with the human Rad51 proteinp53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageThe inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesisHuman TAFII31 protein is a transcriptional coactivator of the p53 proteinp53 is linked directly to homologous recombination processes via RAD51/RecA protein interactionCytoplasmic p53 polypeptide is associated with ribosomesAcetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitroMapping of the p53 and mdm-2 interaction domainsp53 oligomerization and DNA looping are linked with transcriptional activationThe dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA bindingAnalysis of a protein-binding domain of p53Regulation of Mdm2-directed degradation by the C terminus of p53.The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.Regulation of the mdm2 oncogene by thyroid hormone receptorStimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization.The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.Strategies for manipulating the p53 pathway in the treatment of human cancer.Tracing the protectors path from the germ line to the genome.Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.Sequence-specific transcriptional activation is essential for growth suppression by p53.Specific sequences from the carboxyl terminus of human p53 gene product form anti-parallel tetramers in solutionFunctional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.The p53 protein is an unusually shaped tetramer that binds directly to DNA.Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.Epstein-Barr virus nuclear protein 2A forms oligomers in vitro and in vivo through a region required for B-cell transformation.Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.p53 domains: structure, oligomerization, and transformation.Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.Mutation of the endogenous p53 gene in cells transformed by HPV-16 E7 and EJ c-ras confers a growth advantage involving an autocrine mechanism.Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.Stimulation of polyomavirus DNA replication by wild-type p53 through the DNA-binding site.Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
P2860
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P2860
A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
A C-terminal alpha-helix plus ...... minant of p53 tetramerization.
@en
type
label
A C-terminal alpha-helix plus ...... minant of p53 tetramerization.
@en
prefLabel
A C-terminal alpha-helix plus ...... minant of p53 tetramerization.
@en
P2093
P1433
P1476
A C-terminal alpha-helix plus ...... minant of p53 tetramerization.
@en
P2093
Grimaldi M
Jenkins JR
Stürzbecher HW
P304
P407
P577
1992-08-01T00:00:00Z