The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation.
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Cdx binding determines the timing of enhancer activation in postnatal duodenumCloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alphaHeparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epitheliumThe role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporterGata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during developmentChanging genes; losing lactaseDifferential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha.TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regionsPhysical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter.The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation.Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development.Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells.Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2Co-expression of CDX2 and MUC2 in gastric carcinomas: correlations with clinico-pathological parameters and prognosis.Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.Pathological staging and therapy of oesophageal and gastric cancer.A novel CDX2 isoform regulates alternative splicing.Overexpression of caudal-related homeobox transcription factor 2 inhibits the growth of transplanted colorectal tumors in nude mice.Acid, bile, and CDX: the ABCs of making Barrett's metaplasia.The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation.The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1.Ontogeny of brush border carbohydrate digestion and uptake in the chick.Schlafen 3 Mediates the Differentiating Effects of Cdx2 in Rat IEC-Cdx2L1 Enterocytes.Effects of homeodomain protein CDX2 expression on the proliferation and migration of lovo colon cancer cells.CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45.Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2.Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C.Glucagon-like peptide 2 enhances maltase-glucoamylase and sucrase-isomaltase gene expression and activity in parenterally fed premature neonatal piglets.Normal and glucocorticoid-induced development of the human small intestinal xenograft.GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells.T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.Helicobacter pylori induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4-mediated HMG box protein Sox2 expression.Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation.
P2860
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P2860
The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The homeodomain protein Cdx2 r ...... ng enterocyte differentiation.
@en
type
label
The homeodomain protein Cdx2 r ...... ng enterocyte differentiation.
@en
prefLabel
The homeodomain protein Cdx2 r ...... ng enterocyte differentiation.
@en
P2093
P1433
P1476
The homeodomain protein Cdx2 r ...... ng enterocyte differentiation.
@en
P2093
P304
P356
10.1016/S0016-5085(00)70420-3
P407
P577
2000-01-01T00:00:00Z