Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells.
about
I-SceI-induced gene replacement at a natural locus in embryonic stem cellsMice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersTargeted disruption of a human interferon-inducible gene detected by secretion of human growth hormoneTargeted transgenesisEme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsIdentification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cellsPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyAdenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell deathRescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cellsTargeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cellsJunB is essential for mammalian placentationMarked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-IHematopoietic development of vav-/- mouse embryonic stem cellsRetroviruses and cancer: models for cancer in animals and humans.Mutagenic insertion and chromosome engineering resource (MICER).Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both allelesRare homologous gene targeting in Histoplasma capsulatum: disruption of the URA5Hc gene by allelic replacement.Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation.Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinaseMaintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.A transgenic mouse strain expressing four drug-selectable marker genes.A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptorTransgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections.Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells.Functional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients.Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.Modifying the mouse: design and desire.Biallelic targeting of expressed genes in mouse embryonic stem cells using the Cas9 systemModification of the apolipoprotein B gene in HepG2 cells by gene targeting.The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases.Developmental and adult phenotyping directly from mutant embryonic stem cellsModulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells.alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitisRepair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.In vivo analysis of Pim-1 deficiencyDevelopmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development.
P2860
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P2860
Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Consecutive inactivation of bo ...... ation in embryonic stem cells.
@en
type
label
Consecutive inactivation of bo ...... ation in embryonic stem cells.
@en
prefLabel
Consecutive inactivation of bo ...... ation in embryonic stem cells.
@en
P2093
P356
P1433
P1476
Consecutive inactivation of bo ...... ation in embryonic stem cells.
@en
P2093
P2888
P304
P356
10.1038/348649A0
P407
P577
1990-12-01T00:00:00Z
P6179
1035885698