Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment
about
msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentationSuppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNANotch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinasesc-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.Metabotropic glutamate receptors (mGlus) and cellular transformation.Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformationOpposing roles for calcineurin and ATF3 in squamous skin cancer.Angiogenesis, lymphangiogenesis, and melanoma metastasis.Proliferation and neoplastic transformation of pigment cells in metallothionein/ret transgenic mice.Oncogenes in melanomas.Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growthBasic fibroblast growth factor and ultraviolet B transform melanocytes in human skin.Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion geneA marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase.A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas.Fibroblast growth factors in normal and malignant melanocytes.Mechanism of UV-related carcinogenesis and its contribution to nevi/melanomaNotch tumor suppressor functionMalignant melanoma in transgenic mice.Active Notch1 confers a transformed phenotype to primary human melanocytes.Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.The current management of brain metastasis in melanoma: a focus on riluzole.Inhibition of MITF transcriptional activity independent of targeting p300/CBP coactivators.Pigmentation and proliferation of human melanocytes and the effects of melanocyte-stimulating hormone and ultraviolet B light.Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.Signal transduction in normal and malignant melanocytes.Activation of STAT5 triggers proliferation and contributes to anti-apoptotic signalling mediated by the oncogenic Xmrk kinase.Suppression of properties associated with malignancy in murine melanoma-melanocyte hybrid cellsDifferential expression of basic fibroblast growth factor (bFGF) in melanocytic lesions demonstrated by in situ hybridization. Implications for tumor progression.Low level expression of basic FGF upregulates Bcl-2 and delays apoptosis, but high intracellular levels are required to induce transformation in NIH 3T3 cells.Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling.Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE.H-ras ribozyme-mediated alteration of the human melanoma phenotype.Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.Factors associated with melanoma incidence and prognosis.
P2860
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P2860
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Transformation of murine melan ...... stituted cutaneous environment
@en
type
label
Transformation of murine melan ...... stituted cutaneous environment
@en
prefLabel
Transformation of murine melan ...... stituted cutaneous environment
@en
P2093
P2860
P356
P1476
Transformation of murine melan ...... stituted cutaneous environment
@en
P2093
P2860
P304
P356
10.1083/JCB.109.6.3115
P407
P433
P577
1989-12-01T00:00:00Z