about
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyStructure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapiesPreclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor modelsCombined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivoIdentification of novel inhibitors of human Chk1 using pharmacophore-based virtual screening and their evaluation as potential anti-cancer agents.mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibitionTherapeutic targeting of chemoresistant and recurrent glioblastoma stem cells with a proapoptotic variant of oncolytic herpes simplex virus.Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastomaATR/CHK1 inhibitors and cancer therapy.HUS1 regulates in vivo responses to genotoxic chemotherapies.Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions.PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibitionNetwork integration of multi-tumour omics data suggests novel targeting strategies
P2860
Q26745686-CE28B81B-499E-458E-804C-B3E3F1D01288Q26864870-5E7AE3F9-6D1C-4CCF-B404-7BF9BC077C0CQ33578960-DE90EF46-A54F-4154-A211-56E123924837Q33720256-22223917-8A65-45B7-9BC5-15559507DB25Q35329233-0F12BB6A-D39C-4B2D-B2FF-234429ED50A9Q35809470-BC032971-B41C-42D2-86E1-9DBF70B620ECQ40178043-C98AD7F0-BB58-4F4D-AAD5-39D95FD3CACCQ42324653-D8E7F35E-F593-4B30-9D70-5A60476DA665Q47622968-84E2BFCC-FE13-4718-A37C-7CF6D409E782Q48195510-1530EC95-4D83-40D5-87B9-C6D1E7C93C6BQ54977613-2BB13979-323A-4FA5-B608-F00E6765F19DQ57640954-4BE87775-427D-40DA-A046-D88BAEC700E9Q58097633-86D23452-3296-42C5-A55B-DFF7E5399244
P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Enhancing CHK1 inhibitor lethality in glioblastoma.
@en
type
label
Enhancing CHK1 inhibitor lethality in glioblastoma.
@en
prefLabel
Enhancing CHK1 inhibitor lethality in glioblastoma.
@en
P2093
P2860
P356
P1476
Enhancing CHK1 inhibitor lethality in glioblastoma.
@en
P2093
P2860
P304
P356
10.4161/CBT.19240
P50
P577
2012-04-01T00:00:00Z