ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. - Wikidata - awgldk - TriplyDB

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.

http://www.wikidata.org/entity/Q41821426

about

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system Molecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage response In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells.Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage Interplay between oxidant species and energy metabolism TLQP-21 protects human umbilical vein endothelial cells against high-glucose-induced apoptosis by increasing G6PD expression Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation Role of the NADPH Oxidases DUOX and NOX4 in Thyroid Oxidative Stress.Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Decoding NADPH oxidase 4 expression in human tumors.Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway.Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.RAS transformation requires CUX1-dependent repair of oxidative DNA damage.NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.TAp73 promotes anabolism Redox modulation of FAK controls melanoma survival--role of NOX4.Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage.Consequence of the tumor-associated conversion to cyclin D1b Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance.Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice.Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.Interpreting Heterogeneity in Response of Cells Expressing a Fluorescent Hydrogen Peroxide Biosensor.Oxydative stress alters nuclear shape through lamins dysregulation: a route to senescence.HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor Loss of IκB kinase β promotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop.SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1.Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence.NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.Molecular mechanisms underlying chronic inflammation-associated cancers.Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer.Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production

P2860

Q26769965-DAFD537A-5AE6-483C-8DD0-F37D385ED691 Q26991619-AE19D2D8-B45D-4407-990B-FED7D5B771B8 Q27014080-6743994B-9E96-48E9-A989-9358E32AE699 Q27329469-A823AA40-E880-41F4-AD35-28535A108911 Q28270881-A8B038FC-FA3B-4932-84F1-39C214D592BE Q28383905-21351B92-7BE1-4925-87F1-0BFFFC180570 Q28535350-BBC88C03-2F53-4403-878E-F11D7BAA6240 Q33580123-B2557281-5AA3-401C-B2DA-AC840F631496 Q33597583-043F62D7-322A-4DD8-8FA7-7AD8EF8DD3EA Q33613596-03235434-E624-4589-BBA8-181C96765856 Q33761211-6F5EF307-FB0F-4789-8CFE-BC28E81F0CEB Q33761274-06A18F12-9479-482A-9E3A-AD301CEB07B0 Q34035882-328387E0-409A-4107-9ACB-16D465E89812 Q34073807-6D436E2E-A3B2-4CE7-82CF-1D2AC037CE65 Q34327567-60601438-97DB-425D-8146-845FF3E94E2E Q34634278-1B1F0FC5-D9FE-444E-8C6B-72D5C1840862 Q34793661-4D11D841-AD2E-4FBC-9179-BB4CE2AFCFA7 Q35001796-D9BBDC21-8CE9-4985-8D7E-86B5D6BF5341 Q35072584-CCB47F05-E15B-469A-8B90-B00EE84CD8FF Q35117739-2FBF4BEA-101B-44EB-8240-D2C766303757 Q35128895-7D8FBDC9-2367-4946-9414-7CE51C2BEF49 Q35149652-B73913AC-86D0-40C5-BD25-47FCBC954F34 Q35183930-F334F03E-8779-4119-A075-9BBACE14FBEE Q35580962-083372CF-56D5-4153-8B17-43F1F4A88CA6 Q35822584-1EF08206-4FA6-4BC5-860E-8847E584D76D Q35943976-F56D4A95-A952-4EB8-8395-DC193506089E Q35955745-057B74D7-E5EA-415C-8FB9-81858A83791F Q35994479-B263E25A-5CF1-45F5-928A-EE92305D51CC Q36070617-B3608F64-7592-4BC5-BC97-08302DE7E349 Q36252551-5156B5B5-ACB0-4C6A-BBD0-ECDD47B9191A Q36309704-06506973-EFC4-41E0-AD07-66A19152C1A0 Q36328105-B0413D10-90EE-4B84-9438-EDD07A6B3402 Q36457347-4CBAAE66-B3D8-4453-AF82-51363A9F5887 Q36858825-5109EBB4-0B3B-473B-814B-6FD8F0EE6B31 Q37278125-2DAE768A-53F7-41BD-99D8-1BA300988985 Q37309834-3FEC9D77-2B6B-4C90-BB05-1CB19E568D03 Q37548406-B98BEBD4-1D35-4DA1-8B62-9F54759F4696 Q37605343-8202B6D1-D68D-4348-908D-EFCC491538E7 Q37605870-71D762DE-0C72-4D64-8AF5-BDE0A076B369 Q37621112-31215317-FABA-4D4C-8A62-5CF7ECC7A965

P2860

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.

http://www.wikidata.org/entity/Q41821426

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

ROS-generating NADPH oxidase N ...... age and subsequent senescence.

@en

type

label

ROS-generating NADPH oxidase N ...... age and subsequent senescence.

@en

prefLabel

ROS-generating NADPH oxidase N ...... age and subsequent senescence.

@en

P1433

Q41821426-87679FDE-40A0-464C-A663-563922C5A68B

P1476

Q41821426-C9F5586B-0F5A-4AD0-9C60-4A302B9DD822

P2093

Q41821426-01B28575-125A-4E5B-AC5D-B0D5BD033D45

Q41821426-0D857156-8F1E-48A5-A47D-15D2500CB4A1

Q41821426-13DF72A8-3A20-4641-B0C1-7C53A316989A

Q41821426-47B3D8A4-2B6B-45E8-BE9D-29ECCE551D9A

Q41821426-4B4E8934-4D7A-4714-B3EF-1DAEFCC99BF6

Q41821426-5DC24180-367F-4C95-B1D6-156FE88B35F5

Q41821426-62A9F5A2-5DAB-4AE3-A348-96E4EF76F507

Q41821426-9AC6675A-C055-43CF-BEFB-7E26E2734EF0

Q41821426-9D75E234-FB11-4BA7-8250-FAEB53ECC850

Q41821426-ABFE1A0C-4E00-4DCE-A73B-0CE3102E7DE0

P2860

Q41821426-07B53FF7-08C8-430F-8C9B-4DD07319F518

Q41821426-10C823B6-D940-4FCC-8568-D15B91F9917A

Q41821426-19D39C71-5D13-42D3-BC21-A466ECD13DD9

Q41821426-1ACA842E-6545-40FF-8DC1-6B972C2B7229

Q41821426-21362144-C549-458F-B59D-BC10B20F7105

Q41821426-2A175FA7-911D-4908-8819-1D7BF16845B0

Q41821426-3A5094FB-4F61-40B9-B91C-CB6F96A85CE0

Q41821426-3AEBCF95-59B4-41F6-989D-95E801CECD47

Q41821426-3EF01961-4662-410C-B465-468430418508

Q41821426-413F75F2-5B50-4450-A637-EED6C79C6F32

P2888

Q41821426-9454AA5D-540A-4787-B961-90CE853166F6

P304

Q41821426-24C06959-3B10-4BD1-A52A-C3A166DC0E11

P31

Q41821426-7190C89D-8C82-4389-BAFA-834D6756C5B6

P356

Q41821426-BB4321AE-3C13-45E6-A1FD-E0BB3C30D71B

P407

Q41821426-6FB53AE3-80C9-494F-927D-67D5D292771F

P433

Q41821426-12FB0A87-844A-46D9-AE2E-267C221250A4

P478

Q41821426-EE7D3E4A-F043-4353-A4ED-D1AD3C6E484C

P577

Q41821426-54AB5F5A-81E9-4D37-AA7D-98E865A5D289

P5875

Q41821426-CD85EC4E-8816-424A-A806-3638EB27C8AE

P6179

Q41821426-6AA9545C-BA07-43CC-96F9-78A17829C9F3

P698

Q41821426-530C058C-B1E8-46F7-B7CB-489A1EC09A7A

P921

Q41821426-17F51B10-FFCA-419D-AB7E-ECBE9BB71E40

P932

Q41821426-CFA46C08-84EC-4842-AB05-BDAA45FEDEDC

P356

P1433

P1476

ROS-generating NADPH oxidase N ...... age and subsequent senescence.

@en

P2093

A Al Ghuzlan

http://www.w3.org/2001/XMLSchema#string

B Caillou

http://www.w3.org/2001/XMLSchema#string

C Dupuy

http://www.w3.org/2001/XMLSchema#string

F Courtin

http://www.w3.org/2001/XMLSchema#string

F Prenois

http://www.w3.org/2001/XMLSchema#string

J-M Bidart

http://www.w3.org/2001/XMLSchema#string

M Boufraqech

http://www.w3.org/2001/XMLSchema#string

M Dardalhon

http://www.w3.org/2001/XMLSchema#string

M Schlumberger

http://www.w3.org/2001/XMLSchema#string

M Talbot

http://www.w3.org/2001/XMLSchema#string

P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Identification of renox, an NAD(P)H oxidase in kidney

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

P2888

P304

1117-1129

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/ONC.2011.327

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

31

http://www.w3.org/2001/XMLSchema#string

P577

2011-08-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51571654

http://www.w3.org/2001/XMLSchema#string

P6179

1046847048

http://www.w3.org/2001/XMLSchema#string

P698

21841825

http://www.w3.org/2001/XMLSchema#string

P921

P932

3307059

http://www.w3.org/2001/XMLSchema#string