T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs.
about
CD3 delta establishes a functional link between the T cell receptor and CD8Clonal anergy induced in a CD8+ hapten-specific cytotoxic T-cell clone by an altered hapten-peptide ligandT-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APCA CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivityCross-reactivity in T-cell antigen recognition.Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells.A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function.Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptorLoss of T cell-mediated antitumor immunity after construct-specific downregulation of retrovirally encoded T-cell receptor expression in vivo.A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.On the role of self-recognition in T cell responses to foreign antigen.T-cell-mediated autoimmunity: novel techniques to characterize autoreactive T-cell receptorsSurface T-cell antigen receptor expression and availability for long-term antigenic signaling.T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytesPeripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells.T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation.The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggeringPartially phosphorylated T cell receptor zeta molecules can inhibit T cell activation.Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cellsThe T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiationEngaged and bystander T cell receptors are down-modulated by different endocytotic pathways.A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity.Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.A mathematical analysis of TCR serial triggering and down-regulation.Altered superantigenic ligands demonstrate the quantitative nature of T-cell activation.
P2860
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P2860
T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
T cell receptor (TCR) antagoni ...... pressing two independent TCRs.
@en
type
label
T cell receptor (TCR) antagoni ...... pressing two independent TCRs.
@en
prefLabel
T cell receptor (TCR) antagoni ...... pressing two independent TCRs.
@en
P2093
P2860
P356
P1476
T cell receptor (TCR) antagoni ...... pressing two independent TCRs.
@en
P2093
P2860
P304
P356
10.1084/JEM.189.2.253
P407
P577
1999-01-01T00:00:00Z