Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.
about
The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognitionMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionDARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.Small-world networks of residue interactions in the Abl kinase complexes with cancer drugs: topology of allosteric communication pathways can determine drug resistance effects.Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cellsSurvey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites.Combination of In Silico Analysis and In Vitro Assay to Investigate Drug Response to Human Epidermal Growth Factor Receptor 2 Mutations in Lung Cancer.Allosteric Modulation of Src Family Kinases with ATP-Competitive Inhibitors.
P2860
Q27698320-909D4422-612D-463F-BA47-1EA98E5FD014Q28548366-0D4CB6E1-EE15-4168-9546-ED7A647B2788Q36447801-A341E00D-535A-48DC-967C-FDAFCA02E101Q38959137-2E5D8E9A-8133-495D-9F69-66B621A9ADE1Q39277365-5AB4B310-3F3A-4C58-843F-4C7570E4BA98Q39734806-642B2505-35CF-416D-972E-E843A5212514Q41309405-A201D38E-F96E-4D1F-B41D-107301CD7D18Q42223215-AAC5C4ED-5826-4A27-A447-34C8EB71FA0DQ47279026-2A7AD7D9-084E-4C7A-90B6-ACFFAA5BAF77Q49136595-001C960A-7C1E-49BE-A7E6-8E85CEAF6E81Q50878641-1418EE1C-5B99-4534-80C7-92B124FABED8
P2860
Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Conformation-selective inhibit ...... tyrosine kinases Abl and Src.
@en
type
label
Conformation-selective inhibit ...... tyrosine kinases Abl and Src.
@en
prefLabel
Conformation-selective inhibit ...... tyrosine kinases Abl and Src.
@en
P2860
P50
P356
P1433
P1476
Conformation-selective inhibit ...... e tyrosine kinases Abl and Src
@en
P2093
B Gayani K Perera
Pratistha Ranjitkar
P2860
P304
P356
10.1021/CB400663K
P577
2013-10-29T00:00:00Z