Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo - Wikidata - awgldk - TriplyDB

Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo

Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo

http://www.wikidata.org/entity/Q41881074

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More paths to PI3Kγ PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain Phosphatidylinositol 3-kinase: the oncoprotein.PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis.PI3Ks in lymphocyte signaling and development The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.Signal transduction and chemotaxis in mast cells The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress Inhibition of phosphoinositide 3-kinase delta attenuates experimental autoimmune encephalomyelitis in mice p110δ PI3 kinase pathway: emerging roles in cancer.The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites.Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.The multiple roles of phosphoinositide 3-kinase in mast cell biology.Class I PI3K in oncogenic cellular transformation.PI 3-kinase and cancer: changing accents Mechanisms of mast cell signaling in anaphylaxis.Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis?Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.Immunoglobulin E receptor signaling and asthma Phosphoinositide 3-kinase p110γ in immunity.Selective PI3Kδ inhibitors, a review of the patent literature.B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.Pharmacotherapy of allergic rhinitis: current options and future perspectives.PI3-kinase inhibitors in chronic lymphocytic leukemia.Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.PI3K inhibitors in inflammation, autoimmunity and cancer.PTEN and PI3K/AKT in non-small-cell lung cancer.Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease.Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.

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Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo

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Isoform-specific functions of ...... mal allergic responses in vivo

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Journal of Immunology

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Isoform-specific functions of ...... mal allergic responses in vivo

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Bart Vanhaesebroeck

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Christian Chabert

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Christian Pasquali

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Christian Rommel

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Hong Ji

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Khaled Ali

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Thomas Rückle

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Wayne P Pearce

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P2860

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

P110delta, a novel phosphoinositide 3-kinase in leukocytes

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

PI3K in lymphocyte development, differentiation and activation

Synthesis and function of 3-phosphorylated inositol lipids

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

Phosphoinositide 3-kinase: diverse roles in immune cell activation

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2538-2544

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18250464

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