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p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumorsWill kinase inhibitors make it as glioblastoma drugs?Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory MechanismDistinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemiaGenetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.Physiological regulation of Akt activity and stability.VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis.Expression profiling of exosomal miRNAs derived from human esophageal cancer cells by Solexa high-throughput sequencingTherapeutic Targeting of Myc.Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN geneIkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesisDrugging the PI3 kinome: from chemical tools to drugs in the clinic.High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy.Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell CancerThe Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer.p110δ PI3 kinase pathway: emerging roles in cancer.Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling.The role of autophagy in tumour development and cancer therapy.Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors.AKT-independent PI3-K signaling in cancer - emerging role for SGK3.EGFR inhibitors and autophagy in cancer treatment.TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling.High purity microfluidic sorting and analysis of circulating tumor cells: towards routine mutation detection.Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors.Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal cancer.Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow.MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells.PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts.MicroRNA-92a functions as an oncogene in colorectal cancer by targeting PTEN.Updates and achievements in virology.PI3K gain of function mutants phosphorylate PIP2 to PIP3The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
PI 3-kinase and cancer: changing accents
@en
PI 3-kinase and cancer: changing accents.
@nl
type
label
PI 3-kinase and cancer: changing accents
@en
PI 3-kinase and cancer: changing accents.
@nl
prefLabel
PI 3-kinase and cancer: changing accents
@en
PI 3-kinase and cancer: changing accents.
@nl
P2860
P1476
PI 3-kinase and cancer: changing accents
@en
P2093
Marco Gymnopoulos
P2860
P356
10.1016/J.GDE.2008.11.011
P577
2009-02-01T00:00:00Z