Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.
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Phospholipase D as a therapeutic target in brain disordersMammalian phospholipase D physiological and pathological rolesDesign, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitorFunctional regulation of phospholipase D expression in cancer and inflammationNext-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis'Regulation of mTORC1 by PI3K signalingPlatelet lipidomics: modern day perspective on lipid discovery and characterization in plateletsBlood platelets in the progression of Alzheimer's diseasePost-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegenerationThe phospholipase D superfamily as therapeutic targetsPhospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizationsPhospholipases D1 and D2 Suppress Appetite and Protect against OverweightPlatelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema.Thrombotic distal middle cerebral artery occlusion produced by topical FeCl(3) application: a novel model suitable for intravital microscopy and thrombolysis studies.Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla.von Willebrand factor: an emerging target in stroke therapy.Cellular and physiological roles for phospholipase D1 in cancer.Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibitionPhospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerDeficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosisPhospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regenerationPhospholipase D: enzymology, functionality, and chemical modulationSubthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia.The phospholipase D1 pathway modulates macroautophagyThe Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.Physiological and pathophysiological roles for phospholipase D.Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639.Platelet receptor signaling in thrombus formation.Ischaemic stroke: a thrombo-inflammatory disease?Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.Arterial thrombosis--insidious, unpredictable and deadly.The effects of arterial flow on platelet activation, thrombus growth, and stabilization.Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway.
P2860
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P2860
Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Impaired alpha(IIb)beta(3) int ...... mice lacking phospholipase D1.
@en
type
label
Impaired alpha(IIb)beta(3) int ...... mice lacking phospholipase D1.
@en
prefLabel
Impaired alpha(IIb)beta(3) int ...... mice lacking phospholipase D1.
@en
P2093
P2860
P1433
P1476
Impaired alpha(IIb)beta(3) int ...... mice lacking phospholipase D1.
@en
P2093
Attila Braun
Bernhard Nieswandt
Christoph Kleinschnitz
Guido Stoll
Ina Hagedorn
Johan W M Heemskerk
Margitta Elvers
Marijke E J Kuijpers
Michael A Frohman
Michael Boesl
P2860
P356
10.1126/SCISIGNAL.2000551
P577
2010-01-05T00:00:00Z