Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.
about
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge aheadPDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularlyCloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1.Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation.PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation.A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cellsAngiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin.Regulation of insulin-like growth factor (IGF) I receptor expression during muscle cell differentiation. Potential autocrine role of IGF-II.Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines.Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes.Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide.Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factorComplementation of two related tumour cell classes during experimental metastasis tagged with different histochemical marker genes.Absence of constitutive EGF receptor activation in ovarian cancer cell lines.The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complexStromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.Intracellular retention of membrane-anchored v-sis protein abrogates autocrine signal transductionAutocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.Evidence for intracellular down-regulation of the epidermal growth factor (EGF) receptor during adenovirus infection by an EGF-independent mechanism.A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathwayPlatelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein.Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.Mechanism of autocrine stimulation in hematopoietic cells producing interleukin-3 after retrovirus-mediated gene transferDominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cellsc-kit protein, a transmembrane kinase: identification in tissues and characterizationMitogenic regulation of normal and malignant breast epithelium.Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells.Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell lineIndependently arising macrophage mutants dissociate growth factor-regulated survival and proliferation.Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation.Platelet-derived growth factor: mechanism of action and possible in vivo function.Cytokines of the lung.
P2860
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P2860
Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.
@en
type
label
Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.
@en
prefLabel
Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.
@en
P356
P1433
P1476
Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.
@en
P2093
Keating MT
Williams LT
P304
P356
10.1126/SCIENCE.2829358
P407
P577
1988-02-01T00:00:00Z