Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?
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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processingTau clearance mechanisms and their possible role in the pathogenesis of Alzheimer diseaseTangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing ProblemThe lysosome: from waste bag to potential therapeutic targetLysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivoRunning-Induced Systemic Cathepsin B Secretion Is Associated with Memory FunctionCholesterol supports the retinoic acid-induced synaptic vesicle formation in differentiating human SH-SY5Y neuroblastoma cellsProtective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse modelsNeural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degenerationSelective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyPodocytes degrade endocytosed albumin primarily in lysosomesMolecular mechanisms of neurodegeneration in Alzheimer's disease.Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's diseaseOxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse modelFunctional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Autophagy in dementias.Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseasesPassive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain.Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons.Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome ActivityMolecular and cellular mechanisms of excitotoxic neuronal death.Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.Cysteine cathepsins in neurological disorders.Role of endolysosomes and cholesterol in the pathogenesis of Alzheimer's disease: Insights into why statins might not provide clinical benefit.Neuroproteomic tools for battling Alzheimer's disease.Differential cytotoxicity responses by dog and rat hepatocytes to phospholipogenic treatments.Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brainAβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.Gephyrin alterations due to protein accumulation stress are reduced by the lysosomal modulator Z-Phe-Ala-diazomethylketone.Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice.Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate.Β-hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells.Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD.Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.Blast waves from detonated military explosive reduce GluR1 and synaptophysin levels in hippocampal slice cultures.
P2860
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P2860
Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Lysosomal activation is a comp ...... for slowing Alzheimer disease?
@en
type
label
Lysosomal activation is a comp ...... for slowing Alzheimer disease?
@en
prefLabel
Lysosomal activation is a comp ...... for slowing Alzheimer disease?
@en
P2860
P356
P1476
Lysosomal activation is a comp ...... for slowing Alzheimer disease?
@en
P2093
Ben A Bahr
Jennifer Bendiske
P2860
P304
P356
10.1093/JNEN/62.5.451
P577
2003-05-01T00:00:00Z