The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. - Wikidata - awgldk - TriplyDB

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

http://www.wikidata.org/entity/Q38442115

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Regulation of microglial survival and proliferation in health and diseases.Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease Soluble TREM2 induces inflammatory responses and enhances microglial survival.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases TREM2-Ligand Interactions in Health and Disease.The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins.Untangling Genetic Risk for Alzheimer's Disease.The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Intracellular trafficking of TREM2 is regulated by presenilin 1.Vps35-dependent recycling of Trem2 regulates microglial function.The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer.Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.A transcriptomic atlas of aged human microglia.Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2R47H on murine myeloid cell function.Targeting microglia for the treatment of Alzheimer's Disease.TREM1: A Potential Therapeutic Target For Alzheimer's Disease.Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.Microglia in Alzheimer's disease High-affinity interactions and signal transduction between Aβ oligomers and TREM2 The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability

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The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

http://www.wikidata.org/entity/Q38442115

description

2015 nî lūn-bûn

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JBC.M115.677286

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Journal of Biological Chemistry

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The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

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Charles C Bailey

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Lindsey B DeVaux

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

Pattern recognition by TREM-2: binding of anionic ligands

Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.

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26033-26042

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10.1074/JBC.M115.677286

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2015-09-15T00:00:00Z

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